Evidence map›Paper›PMID 41909206›Full record

ArticleJournal of human immunity2026

Refractory infantile IPEX with Treg-restricted FOXP3null expression caused by a novel variant in

Ahmad Rayes, Akshaya Ramachandran, Michael A Pulsipher, J Gregory Dolan, Soohee Cho, Amanda K Johnson, Jessie L Alexander, Simon Borna, Rosa Bacchetta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmad RayesPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-6352-9740
Akshaya RamachandranDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-8727-2046
Michael A PulsipherPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-3030-8420
J Gregory DolanPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-4431-7515
Soohee ChoPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0001-6160-2791
Amanda K JohnsonPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0001-9333-9692
Jessie L AlexanderDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-2756-7301
Simon BornaDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-8445-2634
Rosa BacchettaDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-0606-6268

Funding

Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosageU01AI184132 · NIAID · NATIONAL MARROW DONOR PROGRAM · PI JEFFERY J AULETTA, Michael A Pulsipher · 2024 to 2026
$3.2M
NIAID NIH HHS U01 AI184132
6 · The paper itself

Abstract

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a life-threatening monogenic inborn error of immunity caused by pathogenic variants in the

Identifiers

PMID41909206
PMCPMC13023379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.