Evidence map›Paper›PMID 41909151›Full record

ArticleBiochemistry and biophysics reports2026

Non-linear age-related change in human Interleukin-11 and the receptor subunit alpha DNA methylation.

Akiyoshi Shimura, Varun B Dwaraka, Kyosuke Yamanishi, Tomoteru Seki, Tsuyoshi Nishiguchi, Bun Aoyama, Takaya Ishii, Nathan James Phuong, Nipun Gorantla, Hieu Dinh Nguyen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Akiyoshi ShimuraDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Varun B DwarakaDepartment of Bioinformatics, TruDiagnostic Inc, USA.
Kyosuke YamanishiDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Tomoteru SekiDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Tsuyoshi NishiguchiDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Bun AoyamaDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Takaya IshiiDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Nathan James PhuongDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Nipun GorantlaDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Hieu Dinh NguyenDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Therese SantiagoDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Shota NishitaniDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.
Ryan SmithDepartment of Bioinformatics, TruDiagnostic Inc, USA.
Gen ShinozakiDepartment of Psychiatry and Behavioral Sciences, Stanford University, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Interleukin-11 (IL-11) is a cytokine involved in inflammatory processes and a previous study showed that blocking or knocking down Methods: A genome-wide DNAm database focusing on Cytosine-phosphate-Guanine (CpG) sites within the Results: The database comprised 10,297 samples (5156 males and 5141 females) with a mean age of 53.9 years (SD = 14.1 years). The majority of Conclusion: The observed inverse U-shaped DNAm patterns in the

Identifiers

PMID41909151
PMCPMC13019085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.