ArticleACS physical chemistry Au2026
Single Molecule Force Measurements Reveal Energy Stabilization of Theophylline Aptamer RNA Switch Required for Gene Control.
Article in ACS physical chemistry Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
RNA aptamers play essential roles in gene regulation, sensing, and therapeutics, relying on ligand-induced kinetic changes for function. The theophylline aptamer has been engineered to regulate synthetic gene networks in response to the presence of the theophylline small molecule ligand, but the thermodynamic and kinetic parameters behind theophylline's unique function are not known. Here, we use optical tweezers single-molecule force spectroscopy to measure the folding dynamics of the theophylline aptamer in the presence and absence of ligand. We find that theophylline binding does not affect folding rates but significantly slows unfolding by stabilizing the aptamer by ∼3.6
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