Evidence map›Paper›PMID 41909117›Full record

ArticleCHEST critical care2026

ICU Implementation Determinants and Delivery of Lung Protective Ventilation: A Multihospital Survey and Cohort Study.

Chad H Hochberg, Sophia A Emetu, Kevin J Psoter, Sarina K Sahetya, Meeta P Kerlin, Theodore J Iwashyna, David N Hager, Michelle N Eakin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chad H HochbergDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Sophia A EmetuDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Kevin J PsoterDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Sarina K SahetyaDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Meeta P KerlinDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Theodore J IwashynaDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
David N HagerDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Michelle N EakinDivision of Pulmonary and Critical Care Medicine (C. H. H., S. K. S., T. J. I., D. N. H., and M. N. E.), Department of Medicine (S. A. E.), Department of Pediatrics (K. J. P.), the Bloomberg School of Public Health (T. J. I.), Johns Hopkins University, Baltimore, MD; and the Pulmonary, Allergy and Critical Care Division (M. P. K.), Palliative and Advanced Illness Research Center, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Funding

Driving Pressure as a Target for Lung-Protective VentilationK23HL155507 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SAHETYA, SARINA · 2021 to 2025
$885k
Sustainable Implementation of Prone Positioning for the Acute Respiratory Distress SyndromeK23HL169743 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chad Hochberg · 2023 to 2026
$716k
Mentored implementation science research in asthmaK24HL181392 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Michelle Nuttall Eakin · 2025 to 2026
$241k
NHLBI NIH HHS K23 HL155507NHLBI NIH HHS K23 HL169743NHLBI NIH HHS K24 HL181392
6 · The paper itself

Abstract

backgroundLung protective ventilation (LPV) improves mortality in patients with ARDS and is applied widely in other patients receiving mechanical ventilation. Despite strong evidence, LPV is implemented inconsistently. RESEARCH QUESTION: Are staff-rated ICU implementation determinants associated with delivery of patient-level LPV delivery. STUDY DESIGN AND

methodsWe conducted a cross-sectional survey of ICU clinical staff (January-June 2024) and a retrospective study of patients with hypoxemic respiratory failure receiving mechanical ventilation (January 2023-December 2024). We assessed staff-rated implementation determinants using validated surveys including domains for implementation culture (eg, team cooperation), staff stress, and available resources. We assessed the association of ICU-level survey scores with patient-level LPV (defined as tidal volume [V

resultsSurvey measures from 469 ICU staff (50% response rate) were incorporated into the cohort of 2,120 patients across 5 hospitals and 14 ICUs. Median percentage compliance with LPV on day 1 was 68% (interquartile range, 0%-100%). A 1-SD increase in ICU implementation culture score was not associated with LPV (adjusted rate ratio [aRR], 1.04 [95% CI, 0.95-1.14];

interpretationIn this multihospital study, ICU implementation determinants were associated with receiving V

Indexed as

hypoxemic respiratory failureimplementation sciencemechanical ventilation

Identifiers

PMID41909117
PMCPMC13020689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.