ReviewFrontiers in veterinary science2026
The biological functions of PRRSV nonstructural protein NSP2 in viral infection and replication and its role in host regulatory mechanisms.
Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded, positive-sense arterivirus that causes reproductive and respiratory disorders in sows. It is one of the most important pathogens affecting the global swine industry and is widespread worldwide. To date, PRRSV continues to undergo mutation and evolution. NSP2, as the largest non-structural protein generated via proteolytic cleavage of viral polyproteins, has the highest sequence variability among all PRRSV proteins. It cooperates with other non-structural proteins to orchestrate viral replication and modulate host immune responses. This review systematically summarizes the multifaceted functions of NSP2 in the viral life cycle, including its structural and functional characteristics, relationship with viral virulence, mechanisms in viral replication and assembly, role in host immune regulation, and interaction network with both viral and host proteins. These findings provide a theoretical framework for elucidating PRRSV pathogenesis and immune evasion strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.