Evidence map›Paper›PMID 41908926›Full record

ArticleGenomic psychiatry : advancing science from genes to society2025

Varying levels of interleukin 1 receptor antagonist (

Ma-Li Wong, Claudio Mastronardi, Gilberto Paz-Filho, Charmaine Simeonovic, Julio Licinio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomic psychiatry : advancing science from genes to society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ma-Li WongState University of New York, Upstate Medical University, Syracuse, NY 13210, USA.
Claudio MastronardiINPAC Research Group, Fundación Universitaria Sanitas, Bogotá, Colombia.
Gilberto Paz-FilhoMedical & Scientific Affairs, Johnson & Johnson Innovative Medicine, NSW 2113, Australia.
Charmaine SimeonovicDiabetes and Transplantation Immunobiology Group, Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Julio LicinioState University of New York, Upstate Medical University, Syracuse, NY 13210, USA.

Funding

Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.R01MH127423 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI Julio Licinio, MA-LI WONG · 2022 to 2026
$3.6M
Alternative splicing mechanism in stress.R21MH126405 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LICINIO, JULIO, WONG, MA-LI · 2021 to 2022
$446k
Mechanisms of noncanonical caspase 1 signaling in the brain.R21MH128726 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LICINIO, JULIO, WONG, MA-LI · 2022 to 2023
$446k
NIMH NIH HHS R01 MH127423NIMH NIH HHS R21 MH126405NIMH NIH HHS R21 MH128726
6 · The paper itself

Abstract

The relationship between leptin and interleukin 1 receptor antagonist (IL1RA) is critical to the understanding of obesity's low-grade chronic inflammatory state. IL1RA antagonizes the proinflammatory effects of IL1, dampens systemic inflammation markers, and in clinical trials improved glycemic control in type 2 diabetes. We show that leptin levels decreased relative to the number of

Identifiers

PMID41908926
PMCPMC13026026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.