ArticleMethodsX2026
Extraction and quantification of lead in meconium: Analysis through inductively coupled plasma-mass spectrometer (ICP-MS).
Article in MethodsX, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
In recent years, growing attention has been directed towards the impact of environmental pollution on child health, particularly the silent threat posed by heavy metals (HMs). Foetuses may also be exposed to HMs through placental transfer from the mother. To evaluate such exposures, researchers are increasingly seeking long-term, non-invasive biomatrices, among which meconium - the newborn's first faeces or stool, has emerged as a promising candidate. Meconium accumulates throughout pregnancy and is likely to reflect the transfer of chemicals across the placenta. A total of 136 meconium samples were analysed using ICP-MS to evaluate lead concentration in it. The method achieved a detection limit of 0.00062 µg/g (0.62 ppb). The mean recovery rate of Pb was 101% (range: 93-110%). This study presents the following challenges and solutions: • Extraction, digestion, and quantification of lead (Pb) in human meconium. • Identification of appropriate drying time of meconium samples due to variable water content across samples. • Spiking of meconium with suitable Pb standards, calculation of recovery rates, and estimation of true Pb concentration.
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