Evidence map›Paper›PMID 41908891›Full record

ArticleGastroenterology report2026

Microvillus inclusion disease-associated MYO5B deficiency impairs endosome-to-mitochondrion iron transfer.

Chang Sun, Changsen Leng, Mingyue Sun, Yuan Lin, Mingqian Xu, Águeda Martinez-Barriocanal, Albert Gerding, Jeroen Kuipers, Jim de Leeuw, Barbara M Bakker and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology report, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chang SunDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-1383-0751
Changsen LengDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Mingyue SunDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Yuan LinDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Mingqian XuDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Águeda Martinez-BarriocanalGroup of Molecular Oncology, Biomedical Research Institute of Lleida (IRBLleida), 25198 Lleida, Spain.
Albert GerdingLaboratory of Pediatrics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713GZ Groningen, The Netherlands.
Jeroen KuipersDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Jim de LeeuwDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.
Barbara M BakkerLaboratory of Pediatrics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713GZ Groningen, The Netherlands.
Diego ArangoGroup of Molecular Oncology, Biomedical Research Institute of Lleida (IRBLleida), 25198 Lleida, Spain.
Sven C D van IJzendoornDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, 9713AV Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: MYO5B deficiency causes microvillus inclusion disease (MVID), characterized by the inability to absorb dietary nutrients and secretory diarrhea. MVID intestinal tissue shows metabolic abnormalities, but the causality with MYO5B and the underlying mechanism are unknown. The aim of this study was to determine the effects of MYO5B deficiency on mitochondria as key regulators of cellular metabolism and the underlying mechanism. Methods: Intestinal tissue from MVID patients and inducible intestine-specific Results: MYO5B-deficient Caco2 cells showed fragmented and swollen mitochondria, reduced intra-mitochondrial cristae, defective aerobic respiration, reduced mitochondrial membrane potential, and increased mitochondrial oxidative stress. Introduction of a myc-tagged full-length MYO5B in Conclusion: MYO5B deficiency impairs endosome-to-mitochondrial iron transfer, leading to mitochondrial dysfunction. These results offer a novel therapeutic avenue aimed at restoring mitochondrial function in MVID.

Indexed as

intestinemicrovillus inclusion diseasemitochondriaMYO5B

Identifiers

PMID41908891
PMCPMC13025063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.