ArticleNeuro-oncology pediatrics2026
Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate
Article in Neuro-oncology pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pediatric brain tumors are the leading cause of disease-related mortality in children, yet many aggressive tumors lack effective therapies. RNA splicing is a hallmark of cancer, but it has not yet been systematically studied in pediatric brain tumors. Methods: We analyzed 729 pediatric brain tumors spanning histologies and molecular subtypes to quantify differential tumor splicing. We developed the Results: SBI revealed substantial interhistology and intrahistology heterogeneity. Clusters were enriched for histologies and molecular subtypes, several of which were independently associated with survival beyond histology and clinical covariates. Spliceosome pathway activity varied across clusters and was associated with worse survival, yet was not correlated with SBI, indicating distinct dimensions of splicing dysregulation. Functional prioritization identified a recurrent in Conclusions: This study systematically characterizes splicing in pediatric brain tumors, identifies splicing-informed subgroups, and prioritizes
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