Evidence map›Paper›PMID 41908825›Full record

ArticleFrontiers in pharmacology2026

Baicalin chemosensitivity enhancement of cisplatin in bladder cancer via autophagy flux inhibition.

Jiayi Zhuang, Haojie Wang, Zhaoyin Chen, Jinhua Wang, Xiaoping Zheng, Kancheng He, Dongdong Xie, Qiaoyi Chen, Shiqi Deng, Jiaqing Wu and 2 more

Abstract read
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In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiayi Zhuang *Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Haojie Wang *Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Zhaoyin Chen *Department of Critical Care Medicine, The Second Affiliated Hospital of The Chinese University of HongKong/Longgang District People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
Jinhua WangDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Xiaoping ZhengDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Kancheng HeDepartment of Urology, The First People's Hospital of Foshan, Foshan, Guangdong, China.
Dongdong XieDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Qiaoyi ChenDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Shiqi DengDepartment of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
Jiaqing WuDepartment of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaoqing ZhengDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Yingbo DaiDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cisplatin-based chemotherapy remains the standard treatment for advanced bladder cancer (BC); however, nephrotoxicity and chemoresistance limit its clinical application. Baicalin, a flavonoid metabolite derived from the botanical drug, Materials and Methods: We used cell counting kit (CCK)-8 and 5-ethynyl-2'-deoxyuridine (EdU) assays to explore the role of baicalin in enhancing the sensitivity of BC cells Results: CCK-8 and EdU assays indicated that baicalin significantly enhanced the therapeutic effect of cisplatin and reduced its half maximal inhibitory concentration (IC Conclusion: Baicalin enhanced the sensitivity of BC cells to cisplatin by inhibiting autophagic flux through lysosomal activity suppression. This study provides a potential botanical drug candidate for chemosensitization during BC chemotherapy.

Indexed as

autophagic fluxbaicalinbladder cancerchemosensitivitycisplatin

Identifiers

PMID41908825
PMCPMC13017823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.