ArticleChemical science2026
Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cooperative effects in H-bond networks can be quantified by measuring the effect of an intramolecular H-bond on the association constant for formation of a second intermolecular H-bond with the same functional group. This approach has been used to quantify the cooperativity associated with the interaction of a phosphoryl oxygen with two H-bond donors. A series of compounds that have an intramolecular H-bond between a phosphinamide oxygen and a phenol hydroxyl group were prepared, using substituents on the phenol to vary the strength of the intramolecular H-bond. The presence of the intramolecular interaction was confirmed by NMR spectroscopy in
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