Evidence map›Paper›PMID 41908625›Full record

ArticleJPRAS open2026

Assessment of keloids recurrence rate in patients treated by brachytherapy versus electron beam radiotherapy versus surgical excision.

Nicola Zingaretti, Francesco Paolo Paduano, Francesco De Francesco, Giamaica Conti, Glenda Giorgia Caputo Ammendola, Valeriano Vinci, Francesco Maria Klinger, Pier Camillo Parodi

Abstract read
In one paragraph

Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nicola ZingarettiUniversity of Udine, University Hospital of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, Italy.
Francesco Paolo PaduanoUniversity of Udine, University Hospital of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, Italy.
Francesco De FrancescoAOU Ospedali Riuniti di Ancona, Via Conca 71, Torrette, Italy.
Giamaica ContiUniversity of Verona, Department of Neuroscience Biomedicine and Movement, Piazzale Ludovico Antonio Scuro 10, Verona, Italy.
Glenda Giorgia Caputo AmmendolaUniversity of Udine, University Hospital of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, Italy.
Valeriano VinciIRCCS Humanitas Research Hospital, Via Alessandro Manzoni, 56, Rozzano, Italy.
Francesco Maria KlingerAzienda Ospedaliera San Paolo-Polo Universitario, Via Antonio di Rudinì, 8, Milano, Italy.
Pier Camillo ParodiUniversity of Udine, University Hospital of Udine, Piazzale Santa Maria della Misericordia, 15, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Keloidal scars are benign lesions, and treatment is primarily directed toward symptom relief and cosmetic implications. Given the risk factors, clinical appearance and high recurrence rate, there is no universally accepted treatment. Currently, radiotherapy after surgical excision is recognized as the most efficacious modality. The aim was to compare the efficacy, by means of recurrence rates, between surgical excision alone, electron beam radiotherapy performed after surgical excision, and brachytherapy performed after surgical excision. Material: This retrospective observational study included 27 patients with overall 48 keloids. Patients were divided into three groups: Group 1 (8 patients, 15 keloids) underwent surgical excision alone; Group 2 (10 patients, 19 keloids) received excision plus brachytherapy; Group 3 (9 patients, 14 keloids) received excision plus electron beam radiotherapy. Follow-up evaluations were conducted at 6 months and 2 years. Results: Surgery combined with radiotherapy showed significantly lower recurrence rates compared to surgery alone, confirming its superior efficacy. No significant difference was observed between brachytherapy and electron beam radiotherapy ( Conclusions: The present study confirms that surgical excision of keloids followed by radiotherapy can be an effective method of keloid treatment. Although no significance was found when comparing the two radiotherapeutic modalities, brachytherapy showed better clinical advantage when treating larger lesion as well as alleviating the symptoms caused by keloids.

Indexed as

BrachytherapyElectron beam therapyHypertrophic scarsKeloidsRadiotherapySurgery

Identifiers

PMID41908625
PMCPMC13019933

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.