Evidence map›Paper›PMID 41908617›Full record

ArticleKidney medicine2026

Quantifying Change in Proteinuria After Acute Kidney Injury Among Patients With Chronic Kidney Disease: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Y Diana Kwong, Kathleen D Liu, Alan S Go, Anthony N Muiru, Ian E McCoy, Matthew R Weir, Mark L Unruh, Hernan Rincon-Choles, L Lee Hamm, Jing Chen and 4 more

Abstract read
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In one paragraph

Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Y Diana KwongDivision of Nephrology, University of California San Francisco, San Francisco, CA.
Kathleen D LiuDivision of Nephrology, University of California San Francisco, San Francisco, CA.
Alan S GoDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Anthony N MuiruDivision of Nephrology, University of California San Francisco, San Francisco, CA.
Ian E McCoyDivision of Nephrology, University of California San Francisco, San Francisco, CA.
Matthew R WeirDivision of Nephrology, Department of Medicine, University of Maryland Medical Center, Baltimore, MD.
Mark L UnruhDivision of Nephrology, University of New Mexico, Albuquerque, NM.
Hernan Rincon-CholesDepartment of Kidney Medicine, Cleveland Clinic Foundation, Cleveland, OH.
L Lee HammDepartment of Medicine, Tulane University, New Orleans, LA.
Jing ChenDivision of Nephrology, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX.
Jesse Y HsuDivision of Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Xiaoming ZhangDivision of Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Chi-Yuan HsuDivision of Nephrology, University of California San Francisco, San Francisco, CA.
CRIC Study Investigators

Funding

Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5M
NIDDK NIH HHS U24 DK060990
6 · The paper itself

Abstract

Rationale & Objective: Quantifying the change in proteinuria after acute kidney injury (AKI) may shed light on the pathway through which AKI contributes to kidney disease progression. Study Design: Prospective cohort study of patients with chronic kidney disease (CKD). Setting & Participants: 3,197 participants who were enrolled in the multicenter, prospective Chronic Renal Insufficiency Cohort between January 7, 2013, and January 12, 2021. Exposure: AKI was defined as ≥1.5 peak to nadir inpatient serum creatinine ascertained during a hospital admission. Outcomes: Natural log-transformed urinary protein-creatinine ratio (UPCR) ascertained at annual Chronic Renal Insufficiency Cohort research study visits. Analytical Approach: Mixed-effects regression. Results: Among 3,197 participants, the mean age was 65 years, 44% were women, and 42% self-identified as non-Hispanic Black. The median baseline estimated glomerular filtration rate was 52 mL/min/1.73 m Limitations: Hospitalized AKI with baseline CKD only, predominance of stage 1 AKI, timing of proteinuria collection was limited to annual visits, residual confounding. Conclusions: Among CKD patients, AKI was independently associated with worsening proteinuria (independent of changes in blood pressure or renin-angiotensin system inhibitor use) and may reflect residual structural damage to the kidneys. However, the increase in proteinuria among patients with CKD after AKI was small.

Indexed as

Acute kidney injurycohortproteinuria

Identifiers

PMID41908617
PMCPMC13019561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.