ArticleInfection and drug resistance2026
Risk Factors for Sepsis in Pediatric All During Induction Chemotherapy-Induced Neutropenia: A Single-Center Retrospective Study.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Development and Validation of a Prediction Model for Early ARDS in Children with Sepsis in the PICU: A Multicenter Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To identify clinical factors associated with sepsis during induction chemotherapy-induced neutropenia (CIN) in children with acute lymphoblastic leukemia (ALL). Methods: This single-center retrospective study included 292 children with ALL who received induction chemotherapy between January 2019 and July 2024. Candidate variables were extracted within 24 hours after the first onset of CIN. Sepsis was defined using the pediatric Sequential Organ Failure Assessment (pSOFA). Univariable Cox regression, collinearity assessment using variance inflation factor (VIF), and multivariable Cox regression analyses were performed to identify risk factors associated with time to sepsis. Kaplan-Meier analyses were used to illustrate sepsis-free survival according to key factors. Results: Sepsis occurred in 48/292 (16.4%) patients. In multivariable analysis, oral mucosal status (HR=1.336, 95% CI: 1.061-1.681, P=0.014), C-reactive protein to albumin ratio (CAR) (HR=1.407, 95% CI: 1.088-1.806, P=0.050), red cell distribution width (RDW) (HR=1.126, 95% CI: 1.028-1.233, P=0.011), and procalcitonin (PCT) (HR=1.017, 95% CI: 1.002-1.036, P=0.043) were independently associated with sepsis risk. Kaplan-Meier analyses showed significantly different sepsis-free survival across strata of these factors (all P<0.05). Conclusion: Oral mucosal status, CAR, RDW, and PCT were independently associated with sepsis risk during CIN in children with ALL. These findings may inform early risk assessment and warrant confirmation in larger, multicenter cohorts.
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