ArticleCureus2026
Metastatic Colorectal Cancer as a Chronic Disease: Twelve-Year Survival After Initially Unresectable Bilobar Liver Metastases.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic colorectal cancer is usually associated with limited long-term survival, especially when the disease is extensive or initially considered unresectable. In such situations, survival extending beyond a decade is uncommon and typically confined to very carefully selected patients. We report the case of a 61-year-old woman with sigmoid colon adenocarcinoma who developed extensive bilobar liver metastases that were initially not amenable to surgery. Over a disease course lasting 12 years, she experienced multiple recurrences involving the liver, lungs, and brain. Management included multi-line systemic chemotherapy, delayed hepatic resections after tumor downstaging, repeated locoregional ablative procedures, and participation in an early-phase immunotherapy trial. Despite substantial treatment-related toxicity, disease control was maintained for many years before eventual progression. This case illustrates that metastatic colorectal cancer can occasionally follow a prolonged, relapsing course resembling a chronic illness. It emphasizes the potential value of repeated reassessment of resectability, integration of local therapies, and coordinated multidisciplinary care in selected patients.
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