Adaptation of visual responses in degenerating

Objective: Visual adaptation is a physiological and perceptual process by which the visual system adjusts to changes in the environment or visual stimuli. This process is fundamental to how we perceive the world around us and allows our visual system to efficiently encode and process visual information. The retina incorporates adaptation within its dozens of functionally distinct retinal ganglion cell types. Meanwhile, the field of retinal prostheses is increasing its understanding of electrical adaptation and cell-specific stimulation. However, very little is known about the interaction of visual and electrical stimulation on the adaptation of retinal ganglion cell types. Methods/Approach: Recording with a microelectrode array (MEA), we presented an ON and OFF full-field, visual stimulus to characterize various visual response parameters in healthy and degenerating Main results: A history of electrical stimulation strengthened visual responses in WT retina, even when changes attributable to Significance: Electrical stimulation-induced changes in the retina should be considered in the encoding of visual stimuli by retinal prosthetic devices.