ArticleACS omega2026
Synergistic Effects of CoHCF@MWCNTs@FA Nanocomposites Enhancing Photodynamic Therapy for Triple-Negative Breast Cancer.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
This study presents the synthesis of a ternary nanocomposite containing cobalt hexacyanoferrate, multiwalled carbon nanotubes, and folic acid (CoHCF@MWCNTf@FA) for application in photodynamic therapy (PDT), a minimally invasive approach for the treatment of triple-negative breast cancer. The choice of components was based on their photosensitizing properties and biocompatibility. The nanocomposites showed remarkable stability in biological medium, maintaining their structure and preventing cobalt leakage during incubation. Their efficient internalization by tumor cells (60-70%), particularly for the ternary nanocomposite, highlights the role of receptor-mediated uptake in enhancing the photodynamic response. Cell viability assays in the triple-negative breast cancer cell line (MDA-MB-231) showed that the carbon nanotube (MWCNTf) is noncytotoxic (cell viability ≥ 70%) and the isolated material CoHCF exhibited low cytotoxicity (cell viability ≥ 60%) at the tested concentrations. In contrast, under red light-emitting diode irradiation, the CoHCF@MWCNTf@FA nanocomposite induced 79% cell death at concentrations of 0.8 and 1.0 mg mL
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