Evidence map›Paper›PMID 41908375›Full record

ArticleACS omega2026

Fluoxetine Acts as a Calcium-Dependent Sensitizer of TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Shanay H Desai, Nicole S Sarna, Allen C Luo, Michael R King

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shanay H DesaiDepartment of Neuroscience, Vanderbilt University, 2301 Vanderbilt Place, Nashville, Tennessee 37235, United States.
Nicole S SarnaDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, Texas 77005, United States.ORCID https://orcid.org/0000-0002-5643-5850
Allen C LuoDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, Texas 77005, United States.ORCID https://orcid.org/0000-0001-6995-6586
Michael R KingDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, Texas 77005, United States.ORCID https://orcid.org/0009-0006-4643-3663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited therapeutic options and resistance to apoptosis. TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells through extrinsic death receptor activation and downstream engagement of the intrinsic mitochondrial pathway, yet its therapeutic efficacy is hindered by intrinsic resistance mechanisms. Here, we demonstrate that the widely used antidepressant fluoxetine (FLX) acts as a potent TRAIL sensitizer by driving Ca

Identifiers

PMID41908375
PMCPMC13019251

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.