Evidence map›Paper›PMID 41908350›Full record

ArticleJournal of clinical practice and research2026

Rhabdomyolysis, Acute Kidney Injury, and Exudative Retinal Detachment Associated with Nonsteroidal Anti-Inflammatory Drug and Herbal Product Use: A Case Report.

Sevil Demiray, Alparslan Demiray, Hülya Akgün, Bülent Tokgöz

Abstract readCase Reports
In one paragraph

Article in Journal of clinical practice and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sevil DemirayDepartment of Pathology, Erciyes University Faculty of Medicine, Kayseri, Türkiye.
Alparslan DemirayDepartment of Nephrology, Erciyes University Faculty of Medicine, Kayseri, Türkiye.
Hülya AkgünDepartment of Pathology, Erciyes University Faculty of Medicine, Kayseri, Türkiye.
Bülent TokgözDepartment of Nephrology, Erciyes University Faculty of Medicine, Kayseri, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rhabdomyolysis is a potentially life-threatening condition that may lead to acute kidney injury (AKI). Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, diclofenac-associated rhabdomyolysis is exceedingly rare. Herbal products, often perceived as harmless, may also contribute to nephrotoxicity through contamination or pharmacokinetic interactions. Case Report: A 20-year-old woman presented with muscle pain, weakness, and dark-colored urine after using diclofenac potassium and a homemade herbal mixture. Laboratory findings revealed severe rhabdomyolysis and AKI. Kidney biopsy confirmed myoglobin-induced acute tubular injury. During treatment, the patient developed hypertension and blurred vision; ophthalmologic evaluation revealed exudative retinal detachment. Hemodialysis, ultrafiltration, and blood pressure control resulted in complete renal and visual recovery. Conclusion: This case highlights the unpredictable toxicity that may arise from the combined use of NSAIDs and herbal products. Clinicians should routinely inquire about herbal supplement use, particularly in patients presenting with unexplained rhabdomyolysis or AKI.

Indexed as

Acute kidney injuryherbal productnonsteroidal anti-inflammatory drugretinal detachmentrhabdomyolysis

Identifiers

PMID41908350
PMCPMC13022833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.