ArticleJournal of clinical practice and research2026
Impact of Oxacillinase-48 (OXA-48) and New Delhi Metallo-β-Lactamase (NDM) Co-existence on Mortality in Critically Ill Patients with
Article in Journal of clinical practice and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ceftazidime-Avibactam Versus Colistin-Based Regimens for Carbapenem-Resistant Enterobacterales Bloodstream Infections: A Six-Year Retrospective Cohort and 30-Day Mortality Analysis.Microorganisms · 2026Article
- In silico genomic analysis of resistome, virulome, and mobilome of β-lactamase-producing Klebsiella pneumoniae.Scientific reports · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Carbapenem-resistant Materials and Methods: This prospective study included 83 adult patients with CRKp bacteremia at Kayseri City Training and Research Hospital between September 2023 and March 2024. The control group consisted of patients without infection from the same hospital units. Pathogens were identified using the Vitek 2 system. Susceptibility to ceftazidime-avibactam and colistin was determined using disk methods. Carbapenemase genes were detected by polymerase chain reaction (PCR). Results: In the multivariable logistic regression analysis, central venous catheter use, rectal colonization, and prior piperacillin-tazobactam use were identified as significant risk factors for CRKp bacteremia. Among the isolates, 95% carried OXA-48, 48.2% carried NDM, and 3.6% carried Conclusion: This study demonstrates that OXA-48 remains the most prevalent carbapenemase type in CRKp bloodstream infections in Türkiye, while NDM is increasing rapidly and frequently co-occurs with OXA-48, worsening clinical outcomes. Strengthening infection control measures, promoting the prudent use of antibiotics, and ensuring access to new treatment agents are crucial for reducing the spread and impact of CRKp infections.
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