ArticleNeuropsychiatric disease and treatment2026
Comparative Evaluation of CT and MRI in Detecting Intracranial and Extracranial Manifestations of Tuberous Sclerosis Complex.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by the formation of benign tumors in multiple organs. Neuroimaging plays a pivotal role in diagnosis and surveillance of intracranial and extracranial manifestations. Objective: To evaluate and compare the diagnostic performance of CT and MRI in detecting intracranial and extracranial lesions associated with TSC. Methods: A retrospective analysis was conducted on imaging data from 57 patients diagnosed with TSC. Cranial CT and routine MRI findings were reviewed and compared. In addition, abdominal and thoracic CT findings were evaluated for renal, hepatic, pulmonary, and skeletal involvement. Results: Subependymal calcified nodules were observed in 51/57 (89.5%) patients, with a CT detection rate of 100% (46/46), significantly higher than routine MRI (68.4%, 13/19; Conclusion: CT and routine MRI demonstrated lesion-specific, complementary roles in TSC. CT preferentially identified calcified lesions and delineated extracranial multisystem involvement, whereas MRI offered an advantage in the detection of cortical dysplasia and other soft-tissue abnormalities. Integrating intracranial and extracranial imaging within a single cohort, this study supported a practical, modality-tailored CT-MRI approach for comprehensive assessment and risk-adapted surveillance in TSC.
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