Evidence map›Paper›PMID 41908286›Full record

ArticleFrontiers in neurology

Systemic immune-inflammation index and systemic inflammation response index: novel hematological predictors of obstructive sleep apnea.

Guohua He, Mingzhu Deng, Yangping Tong, Zhen Wan, Wei Xu, Tieqiao Feng, Wengao Zeng, Ling Xiao, Dandan Yang, Kangping Song and 1 more

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Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Guohua He *Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Mingzhu Deng *Department of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China.
Yangping Tong *Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Zhen WanDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Wei XuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Tieqiao FengDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Wengao ZengDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Ling XiaoDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Dandan YangDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Kangping SongDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Fangyi LiDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While the association between obstructive sleep apnea (OSA) and chronic inflammation is well-established, the role of novel hematological indices, such as the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), remains unclear. Their specific relationship with OSA has not been fully elucidated. Methods: A total of 590 consecutive patients with suspected OSA were enrolled between June 2023 and August 2025. OSA was defined as an apnea-hypopnea index (AHI) of ≥5 events per hour. Spearman's rank correlation analysis was used to assess the relationships among SII, SIRI, AHI, and the lowest SpO₂. Logistic regression analyses were performed to examine the associations of SII and SIRI with OSA. Sensitivity analyses were conducted to evaluate the robustness of the findings. Receiver operating characteristic (ROC) curves were generated to assess the discriminative ability of SII and SIRI in identifying patients with OSA. Results: Of the 590 patients included in the study, 413 (70%) were diagnosed with OSA. Spearman rank correlation analysis revealed that both SII ( Conclusion: Our findings demonstrate that both the SII and SIRI are independent risk factors for OSA and may serve as potential biomarkers for identifying individuals with OSA.

Indexed as

apnea-hypopnea indexinflammationobstructive sleep apneasystemic immune-inflammatory indexsystemic inflammation response index

Identifiers

PMID41908286
PMCPMC13017371

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