ArticleFrontiers in bioengineering and biotechnology2026
ECM proteins regulate microRNA-mediated direct reprogramming of fibroblasts into cardiomyocytes via YAP signaling.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Direct cardiac reprogramming represents a promising strategy to regenerate damaged myocardium by converting cardiac fibroblasts into induced cardiomyocytes (iCMs). Transient delivery of a four-microRNA cocktail (miRcombo: miR-1, miR-133, miR-208, and miR-499) has been shown to activate cardiac transcriptional programs in adult human cardiac fibroblasts (AHCFs). However, Methods: An Results: Biomatrix significantly enhanced reprogramming efficiency, yielding approximately 20% cardiac Troponin T (cTnT) Discussion: These findings demonstrate that ECM biochemical cues are key regulators of direct cardiac reprogramming. Laminin- and biomatrix-enriched microenvironments enhance miRcombo-mediated iCM induction efficiency
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