ArticleHeart rhythm O22026
Personalized in vitro models reveal functional impact of a
Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- mRNA-Lipid Nanoparticle-Mediated Reprogramming and Standard Sendai Virus Reprogramming: Generation of iPSCs and iPSC-Derived Cardiomyocytes.International journal of molecular sciences · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Long QT syndrome is clinically associated with recurrent ventricular tachycardia and sudden cardiac death. Mutations in Objective: We aimed to investigate the pathogenicity and personalized therapy for a patient with LQTS2 carrying a novel Methods: This study aimed to evaluate the expression and function of the channel protein, we conducted immunoblotting and whole-cell patch-clamp recordings. In addition, patient-specific human-induced pluripotent stem cell-derived cardiomyocytes were combined with a heart-on-chip platform to validate the pathogenicity of this heterozygous variant and investigate the pharmacologic candidates for phenotypic rescue. Results: In HEK293 cells overexpressing the mutant Conclusion: The F431L mutation in
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Registered trials
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