Evidence map›Paper›PMID 41908160›Full record

ArticleJBMR plus2026

Association between chronic inflammation and poorer long-term functional recovery post-hip fracture in and between men and women.

Marty Eastlack, Zhaoyong Feng, Laurence S Magder, Ram R Miller, Denise L Orwig, Ann Gruber-Baldini, Jay Magaziner, Alice S Ryan

Abstract read
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In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marty EastlackDepartment of Physical Therapy, Arcadia University, Glenside, PA 19038,  United States.
Zhaoyong FengDivision of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201,  United States.
Laurence S MagderDivision of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201,  United States.
Ram R MillerNovartis Pharmaceuticals, Cambridge, MA 02139,  United States.ORCID https://orcid.org/0000-0002-2481-2834
Denise L OrwigDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201,  United States.
Ann Gruber-BaldiniDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201,  United States.ORCID https://orcid.org/0000-0002-0190-1973
Jay MagazinerDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201,  United States.ORCID https://orcid.org/0000-0002-9109-5986
Alice S RyanDivision of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, and Baltimore Geriatric Research Education Clinical Center, Baltimore, MD 21201,  United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanisms underlying functional recovery after hip fracture have not been widely studied in either sex, but particularly not in men. Cytokines, or biomarkers of inflammation in the blood, are associated with declines in function post hip fracture in women. Therefore, the aim of this study was to examine chronic systemic inflammation, as measured by cytokines, and its association with function and functional recovery post-hospitalization within and between the sexes. In the sample, with equal proportions of men and women, cytokines were measured at baseline, 2, 6, and 12 mo post-hip fracture, including IL1-ra, IL-6, and sTNFα-R1 levels. The Short Physical Performance Battery (SPPB) was measured at 2 and 6 mo. Participants were divided into tertiles based on their 2-mo cytokine levels. Longitudinal regression models were used to examine the change in cytokine levels over the year by sex, and to model the association of cytokine tertiles and physical function. Older adults (

Indexed as

functionhip fractureinflammationlong-term recoverysex differences

Identifiers

PMID41908160
PMCPMC13019678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.