Evidence map›Paper›PMID 41908159›Full record

ArticleJBMR plus2026

Impaired bone matrix turnover with selective small bone fragility in a child with

Alex Guo, Cara Tillotson, Cecilia Sena, Adhirai Muthukumar, Madhulatha Pantrangi, Mythily Ganapathi, Olga Gewartowska, Paweł S Krawczyk, Vidhu V Thaker, Ekaterina Semenova

Abstract read
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alex GuoDivision of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, United States.
Cara TillotsonDivision of Pediatric Endocrinology, Virginia Tech Carilion School of Medicine, Roanoke, VA 24015, United States.
Cecilia SenaDivision of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, United States.
Adhirai MuthukumarDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, United States.
Madhulatha PantrangiDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, United States.
Mythily GanapathiDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, United States.
Olga GewartowskaGenome Engineering Facility, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, 02-109 Poland.
Paweł S KrawczykLaboratory of RNA Biology, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, 02-109 Poland.
Vidhu V ThakerDivision of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, United States.
Ekaterina SemenovaDivision of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, United States.ORCID https://orcid.org/0009-0003-6590-1555

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Genetics of Early Childhood Obesity and its Clinical ImplicationsK23DK110539 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI THAKER, VIDHU V. · 2016 to 2021
$996k
NIDDK NIH HHS K23 DK110539NIDDK NIH HHS P30 DK026687
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) encompasses a genetically diverse spectrum of skeletal dysplasias, commonly linked to pathogenic variants in

Indexed as

Matrix MineralizationmRNA Stabilityosteogenesisosteogenesis imperfectapolyadenylationTENT5A

Identifiers

PMID41908159
PMCPMC13019700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.