Evidence map›Paper›PMID 41908145›Full record

ArticleNeuro-oncology advances

Characterization of patient-derived site-specific

Jessica K R Boult, Diana M Carvalho, Ketty Kessler, Valeria Molinari, Alan Mackay, Yura Grabovska, Mariama Fofana, Kathryn R Taylor, Lynn Bjerke, Elisabet Fernandez and 32 more

Abstract read
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In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Jessica K R BoultCentre for Cancer Imaging, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0002-3990-9663
Diana M CarvalhoCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Ketty KesslerCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Valeria MolinariCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Alan MackayCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Yura GrabovskaCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Mariama FofanaCentre for Cancer Imaging, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
Kathryn R TaylorCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Lynn BjerkeCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Elisabet FernandezCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Rita PereiraCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Matthew ClarkeCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Sara TemelsoCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Anna BurfordCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Drenusha SejdiuCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Angel M CarcabosoInstitut de Recerca Sant Joan de Deu, Barcelona, Spain.
Julia V CockleCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Fernando CarcellerCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Lynley V MarshallCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Sucheta J VaidyaCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Leslie R BridgesNeuropathology, Cellular Pathology, St George's University Hospitals NHS Foundation Trust, London, UK.
Navneet SinghDepartment of Neurosurgery, St George's University Hospitals NHS Foundation Trust, London, UK.
Simon StapletonDepartment of Neurosurgery, St George's University Hospitals NHS Foundation Trust, London, UK.
Samantha HettigeDepartment of Neurosurgery, St George's University Hospitals NHS Foundation Trust, London, UK.
Safa Al-SarrajDepartment of Clinical Neuropathology, King's College Hospital NHS Trust, London, UK (S.A.-S., Z.R.).
Zita ReiszDepartment of Clinical Neuropathology, King's College Hospital NHS Trust, London, UK (S.A.-S., Z.R.).
Bassel ZebianDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Cristina BleilDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Richard G GrundyChildren's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
Juliet C GrayCentre for Cancer Immunology, University of Southampton, Southampton, UK.
Darren HargraveUCL Great Ormond Street Institute for Child Health, London, UK.
Shaun WilsonDepartment of Paediatric Haematology and Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Susan PictonDepartment of Paediatric Oncology and Haematology, Leeds Children's Hospital, Leeds, UK.
Jenny K AdamskiNeuro-oncology Division, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Timothy E G HassallOncology Service, Queensland Children's Hospital, Brisbane, Australia.
Angela MastronuzziResearch Area of Onco-haematology and Pharmaceutical GMP Facility, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-4408-2373
Andrea CaraiNeurosurgery Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-5203-7855
Philip BenjaminDepartment of Neuroradiology, St George's University Hospitals NHS Foundation Trust, London, UK.
G Stefania ColafatiOncological Neuroradiology and Advanced Imaging Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Maria VinciCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0002-7952-6771
Chris JonesCentre for Children and Young People's Cancer, Division of Cancer Biology, The Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0001-8118-2296
Simon P RobinsonCentre for Cancer Imaging, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0003-4101-7274

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is an urgent need for novel targeted therapeutic strategies for pediatric-type diffuse high-grade glioma (PDHGG) to improve patient outcomes, the development of which demands model systems that accurately recapitulate the specific PDHGG subtypes. Characterization, longitudinal monitoring and, ultimately, evaluation of treatment response in these models requires sensitive non-invasive imaging techniques such as magnetic resonance imaging (MRI). Methods: Thirty-five patient-derived, site-specific, orthotopic Results: Median survival ranged from 54 to 433 days. Tumors identified on T Conclusion: We established a comprehensive pre-clinical platform in which to evaluate the efficacy of therapeutic strategies against PDHGG

Indexed as

magnetic resonance imagingorthotopic xenograftspediatric-type diffuse high-grade gliomapre-clinical models

Identifiers

PMID41908145
PMCPMC13023044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.