ArticleFrontiers in psychiatry2026
Changes in regional homogeneity of the social brain in individuals with autism spectrum disorder after social skills training.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study examined changes in regional homogeneity (ReHo) following Social Skills Training (SST) and their association with improvements in social deficits in individuals with autism spectrum disorder (ASD). Methods: 44 adolescents and adults with ASD (aged 12-30) were recruited, 38 participants (20 in training group, 18 in control group, matched for sex, age, and IQ) were retained after quality control of MRI data. The training group underwent magnetic resonance imaging (MRI) scans and assessments of Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) before and after a 14-week SST program, while the control group completed the same MRI scans and assessments at the same time point but did not receive SST. Results: Resting-state functional MRI analyses revealed significant group × condition interactions in five social brain regions, including the right medial frontal gyrus, right insula, and left medial superior frontal gyrus. At the endpoint of SST, the training group showed reduced ReHo in these regions alongside significant decreases in scores of ABC total, social withdrawal factor, SRS total, social awareness, social cognition, social communication factors. The control group, in contrast, showed only limited improvements on specific subscales, while the training group demonstrated a broader pattern of behavioral gains. We also found an exploratory association between the decrease in ReHo of the right medial frontal gyrus and the reduction in the ABC total score in training group. Discussion: These findings indicate that SST may modulate local functional connectivity within the social brain networks, and these connectivity changes may correlate with observed behavioral improvements.
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