ReviewOncoTargets and therapy2026
A Review of SIK2 in Ovarian Cancer: Function and Emerging Targeted Therapies.
Review in OncoTargets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian cancer, a common gynecologic malignancy, is associated with a poor prognosis owing to difficulties in early detection, high recurrence rates, and frequent therapy resistance. Salt-inducible kinase 2 (SIK2), a serine/threonine kinase frequently overexpressed in ovarian cancer, has emerged as a potential key driver of tumor progression. It is implicated in diverse processes, including metabolic reprogramming, cell proliferation, DNA damage repair, metastasis, and chemoresistance. Consequently, SIK2 is increasingly recognized as a promising target for developing novel therapeutic strategies. Unlike previous reviews that broadly cover the SIK family or general ovarian cancer metabolism, this review provides a SIK2-centered perspective, comprehensively synthesizing its multifaceted oncogenic roles and systematically evaluating emerging targeted therapies-including ATP-competitive inhibitors (ARN-3261, MRIA9), a protein degrader (SIC-19), and a novel hydrogel delivery system (Gel Nap-S+HG). Despite these promising developments, it is important to note that most SIK2-targeted agents are still in preclinical stages, and several critical hurdles remain to be addressed before clinical translation-including off-target toxicity, limited selectivity, and the lack of validated predictive biomarkers for patient stratification. By integrating current mechanistic insights with an up-to-date evaluation of emerging therapies, this review provides a foundational framework for guiding future research and supporting the clinical development of SIK2-targeted strategies in ovarian cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.