Evidence map›Paper›PMID 41908074›Full record

ArticleOral science and homeostatic medicine2026

NRF2 Stabilization by Isoform-Specific Nuclear Phosphoinositides in Stress Response.

Yiting Tang, Yu Chen, Noah D Carrillo, Vincent L Cryns, Richard A Anderson, Jichao Sun, Mo Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral science and homeostatic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiting TangDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen 518055, China.
Yu ChenDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen 518055, China.
Noah D CarrilloUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, 53705, USA.
Vincent L CrynsUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, 53705, USA.
Richard A AndersonUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, 53705, USA.
Jichao SunDepartment of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.
Mo ChenDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen 518055, China.

Funding

Phosphoinositide Signaling in the Cytosol and NucleusR35GM134955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson · 2020 to 2026
$5.0M
NIGMS NIH HHS R35 GM134955
6 · The paper itself

Abstract

Phosphoinositide signaling has long been regarded as a membrane-confined regulatory system; however, emerging evidence reveals a distinct nuclear lipid signaling axis that directly regulates protein stability. A recent study details a previously unrecognized mechanism controlling nuclear factor erythroid 2-related factor 2 (NRF2), demonstrating that oxidative stress induces its stabilization through a nuclear complex composed of type I phosphatidylinositol 4-phosphate 5-kinase γ (PIPKIγ), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P

Indexed as

NRF2NucleusPIPKIγPIP signalingPtdIns(4,5)P2

Identifiers

PMID41908074
PMCPMC13021284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.