Evidence map›Paper›PMID 41908055›Full record

ArticleFrontiers in cardiovascular medicine2026

Impact of diagnosis-to-ablation time on left atrial remodeling and voltage-guided ablation outcome in persistent atrial fibrillation patients.

Halim Marzak, François Severac, Clément Baldacini, Simon Fitouchi, Loic Faucher, Julien Jacques, Thomas Cardi, Mohamad Kanso, Alexandre Schatz, Patrick Ohlmann and 2 more

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Halim MarzakDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
François SeveracPublic Health Service, Groupe Méthodes en Recherche Clinique (GMRC), Strasbourg University Hospital, Strasbourg, France.
Clément BaldaciniDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Simon FitouchiDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Loic FaucherDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Julien JacquesDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Thomas CardiDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Mohamad KansoDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Alexandre SchatzDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Patrick OhlmannDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Olivier MorelDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.
Laurence JeselDivision of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Delayed catheter ablation (CA) has been associated with higher rates of atrial fibrillation (AF) recurrence. Low-voltage zones (LVZs) are established predictors of AF recurrence after CA. Data on LVZ assessment in relation to diagnosis-to-ablation time (DAT) remain limited. This study aimed to evaluate the extent of left atrial (LA) LVZs, bipolar voltage, and the outcomes of voltage-guided CA in patients with persistent AF, classified according to DAT. Methods: We consecutively enrolled 350 patients with persistent AF undergoing their first voltage-guided CA. Patients were classified according to DAT into two groups: DAT ≤1 year ( Results: Patients with DAT >1 year exhibited lower LA bipolar voltage ( Conclusion: Patients with persistent AF and a longer DAT displayed more extensive LA substrate remodeling. Despite a tailored ablation targeting LVZs, a longer DAT was associated with a higher rate of AT recurrence. Early ablation within the first year after AF diagnosis could optimize AF CA outcomes.

Indexed as

atrial fibrillationbipolar voltage mapcatheter ablationdiagnosis-to-ablation timelow voltage zonesvoltage-guided ablation

Identifiers

PMID41908055
PMCPMC13017272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.