Evidence map›Paper›PMID 41908046›Full record

ReviewFrontiers in cardiovascular medicine2026

The "floating" valve, a modified bioroot Bentall procedure.

David Derish, Oliver Sebastian Lee, Roupen Hatzakorzian, Dominique Shum-Tim

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David DerishFaculty of Medicine and Health Sciences, McGill University, Montréal, QC, Canada.
Oliver Sebastian LeeUniversity College London Medical School, University College London, London, United Kingdom.
Roupen HatzakorzianDepartment of Anaesthesia, Division of Adult Anaesthesia, McGill University Health Centre, Montréal, QC, Canada.
Dominique Shum-TimDivision of Cardiac Surgery and Surgical Research, McGill University Health Centre, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With a rising incidence of aortic root disease globally, the Bentall procedure remains the gold standard for aortic root replacement. Unfortunately, the classic mechanical heart valves (MHVs) often employed in these surgeries require lifelong anticoagulation, carrying serious bleeding or thrombo-embolic risks and incurring significant lifestyle changes for patients. Recent advances have shifted focus towards biological heart valves (BHVs), leading to the emergence of a bioroot Bentall which can integrate a "floating" BHV within a synthetic vascular conduit. We reviewed contemporary evidence on this surgery to define indications, outcomes and knowledge gaps. This narrative review highlights surgical techniques, patient selection criteria, and surgical outcomes. Uniquely, "floating" valve placement improves hemodynamics and reduces prosthesis-patient mismatch. Additional advantages included valve-in-valve (ViV) feasibility and easier coronary re-access, while persisting barriers were uncertain long-term BHV durability and a lack of long-term randomized evidence. Emerging technologies, such as advanced biomaterials, and global demand for cardiac surgical care, are likely to further popularise this type of bioroot Bentall. Clinical preferences are shifting towards anticoagulation-free solutions, especially for younger, small-annulus, or anti-coagulation-averse patients. The "floating" bioroot Bentall is a compelling alternative to the use of traditional mechanical prostheses, offering a balance between durability and quality of life. Prospective registries and larger head-to-head trials are now required to benchmark floating bioroot Bentall on survival, valve durability, cost-effectiveness, and patient-reported outcomes. Future research should focus on optimizing BHV durability and refining surgical techniques to further improve clinical outcomes.

Indexed as

aortic root replacementBentall operationbioprosthetic valveprosthesis-patient mismatchsurgical innovationvalve degeneration

Identifiers

PMID41908046
PMCPMC13017286

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.