Evidence map›Paper›PMID 41908037›Full record

ArticleFrontiers in cardiovascular medicine2026

Chronic Brucella infection associated with amyloid light chain cardiac amyloidosis: a case report.

RuiXia He, HaiJun Wang, LingMin Wu, Li Li, XinYuan Xu, GuoLi Ma, BaYaEr Qi, LiNa Ji, XiaoPing Liu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

RuiXia HeDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
HaiJun WangDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
LingMin WuClinical EP Laboratory and Arrhythmia Center, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Li LiClinical Pathology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
XinYuan XuDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
GuoLi MaDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
BaYaEr QiDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
LiNa JiDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.
XiaoPing LiuDepartment of Cardiology, Ordos Clinical College of Inner Mongolia Medical University, Ordos Central Hospital, Ordos, Inner Mongolia Autonomous Region, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Amyloidosis is a rare group of diseases characterized by extracellular deposition of amyloid fibrils. The most common types are amyloid light chain (AL) and transthyretin (ATTR), while serum amyloid A (AA) type is relatively rare. Infections are often associated with AA amyloidosis, whereas AL amyloidosis typically results from abnormal proliferation of monoclonal plasma cells. However, the relationship between AL amyloidosis and infections remains unclear. Case presentation: We present the case of a 69-year-old male patient with chronic brucellosis complicated by heart failure. Laboratory tests showed significantly elevated myocardial enzymes and N-terminal pro-B type natriuretic peptide. Cardiac echocardiography and cardiac magnetic resonance imaging revealed abnormal myocardial hypertrophy, and the patient showed poor response to myocarditis-targeted treatment. Outcome: Genetic testing for inherited cardiomyopathies ruled out Fabry disease, hereditary hypertrophic cardiomyopathy, and ATTR amyloidosis-associated abnormal genes. Serum immunofixation electrophoresis indicated positivity for lambda light chain. AL cardiac amyloidosis was confirmed by myocardial biopsy. Conclusion: We report a case of chronic Brucella infection and AL-type cardiac amyloidosis, with a high overlap in clinical onset time. However, additional studies are needed to confirm the potential relationship between Brucella infection and AL-type cardiac amyloidosis.

Indexed as

amyloid light chainBrucella infectionscardiac amyloidosisimmunityinflammation

Identifiers

PMID41908037
PMCPMC13018100

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