ArticleBioinformation2025
Effect of RF and Anti-CCP antibody for Rheumatoid Arthritis diagnosis: A comparative study.
Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Rheumatoid arthritis (RA) is a long-term autoimmune disease that needs to be diagnosed as soon as possible in order to achieve maximum treatment results. Although rheumatoid factor (RF) has been a conventional serologic test, the anti-cyclic citrullinated peptide (anti-CCP) antibodies are now considered a more specific diagnostic test. Therefore, it is of interest to determine the diagnostics performance of RF and anti-CCP antibody tests in suspected RA patients in a tertiary care hospital. One hundred and eighty participants will be recruited, that is, 120 participants diagnosed with RA clinically (according to the 2010 ACR/EULAR definitions) and 60 age-matched controls. RF in serum samples was studied by nephelometry and the anti-CCP antibodies through enzyme-linked immunosorbent assay (ELISA). Anti-CCP antibodies were more specific (96.7% vs. RF, 78.3%), whereas the sensitivity was also similar (81.7% vs. 75.0% respectively). Anti-CCP (96.1) had a better positive predictive value than RF (85.7%). The sensitivity (88.3%) and specificity (95.0%) with combined testing were improved. Anti-CCP was found to have significant correlations with disease activities and radiological erosions. Data shows uphold anti-CCP antibodies as a better diagnostic tool than RF in Diagnosing RA and the combination of the two tests provides the best diagnostic value in the early stages of the disease and prognostication.
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