ArticleClinical ophthalmology (Auckland, N.Z.)2026
Epidemiology, Microbiology, Management and Outcomes of Endophthalmitis: An 18 Year Retrospective Observational Study at a Tertiary Referral Center in Australia.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study characterizes the epidemiology, microbiological profile, management and outcomes of endophthalmitis over 18 years at a tertiary referral center in regional New South Wales (NSW), Australia. Methods: A retrospective observational study of all endophthalmitis cases at John Hunter Hospital (November 2006 to December 2024) identified via ICD-10 codes and confirmed via record review. Data included demographics, clinical presentation, etiology, microbiology, management and surgical interventions. Results: In total, 232 cases (227 patients) were identified (median age 75.6 years). Annual incidence declined significantly (slope = -0.17 cases/year, 95% CI -0.29 to -0.052); p = 0.005). Exogenous endophthalmitis accounted for 87.1% of cases, most commonly following cataract surgery or intravitreal injection (38.1% each). Endogenous cases (12.9%) were mainly associated with bacteremia (56.7%) and immunosuppression (20%). Culture positivity was 56%, with 97.7% of isolates being bacterial. Conclusion: Exogenous endophthalmitis remains the leading cause of endophthalmitis at a major regional tertiary referral center. Findings align with the Endophthalmitis Vitrectomy Study, suggesting vitrectomy benefits mainly eyes presenting with light perception only vision.
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