Evidence map›Paper›PMID 41907769›Full record

ArticleClinical hematology international2026

Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia.

Kian J Rahbari, Parth C Patel, Sarah Profitt, Justin T Kelley, Katie A O'Connell, Anna K Dewan, Kathryn E Kennedy, Erica E Mittlebeeler, Ashwin Kishtagari, Somedeb Ball and 2 more

Abstract readCase Reports
In one paragraph

Article in Clinical hematology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kian J RahbariDepartment of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-6119-3569
Parth C PatelDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah ProfittDepartment of Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USA.
Justin T KelleyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Katie A O'ConnellDepartment of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.
Anna K DewanDepartment of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kathryn E KennedyDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Erica E MittlebeelerDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ashwin KishtagariDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Somedeb BallDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sanjay R MohanDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kateryna FedorovDepartment of Internal Medicine, Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is frequently curable in the modern era using the chemotherapy-free regimen of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, rare disease manifestations and treatment complications may threaten these outcomes by requiring intensification or abbreviation of therapy. We present a unique case of a 36-year-old male with newly diagnosed low-risk APL with biopsy-confirmed leukemia cutis and isolated ATRA-associated myocarditis during induction therapy. Both APL leukemia cutis and ATRA-associated myocarditis are exceedingly rare, with each having less than 50 published cases to date. This report offers a comprehensive review of the literature, underscoring the importance of a comprehensive diagnostic evaluation and individualized care to ensure outstanding long-term outcomes for patients with APL.

Indexed as

acute myeloid leukemiaAcute promyelocytic leukemiaATRA-induced myocarditisleukemia cutis

Identifiers

PMID41907769
PMCPMC13032189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.