ArticleJournal of the Endocrine Society2026
Parathyroid histology in normocalcemic and hypercalcemic primary hyperparathyroidism with hypercalciuric renal stones.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The cross-cultural and chronological evolution of the kidney-bone relationship: from ancient medical insights to modern molecular endocrinology.Frontiers in endocrinology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Hypercalcemic (HPHPT) and normocalcemic primary hyperparathyroidism (NHPT) are distinct conditions with different biological and histological characteristics. Understanding their histological patterns could improve disease characterization. Objective: This study aimed to compare the histological features of NHPT and HPHPT parathyroid glands, but also rims of normal tissue, focusing on the expression of calcium-sensing receptor (CaSR), 1-α hydroxylase (CYP27B1), and vitamin D receptor (VDR). Methods: A retrospective observational study was conducted on histological and immunohistochemical data from parathyroid gland samples. The study included 50 hypercalciuric renal stone patients, of whom 18 had NHPT and 32 had HPHPT. Histological and immunohistochemical analyses were performed to evaluate cell distribution and marker expression. Parathyroid gland weight, cell distribution, and CaSR, CYP27B1, and VDR expression were analyzed and compared between NHPT, HPHPT, and rim biopsies. Results: Parathyroid gland weight and cell distribution were similar in both groups. A rim of normal tissue was more frequent in HPHPT (69% vs 37%; Conclusion: The NHPT hallmark phenotype is normal CaSR, CYP27B1/VDR expression in chief cells, with decreased VDR expression in oxyphil cells. HPHPT chief cell patterns show a marked CaSR decreased expression along with an increased CYP27B1/VDR expression, suggesting an appropriate autocrine/paracrine counterregulation to hypercalcemia/high PTH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.