Evidence map›Paper›PMID 41907623›Full record

ArticleFrontiers in oncology2026

Case Report: Secondary neurolymphomatosis successfully treated with sequential Bruton's tyrosine kinase inhibitor and bispecific antibody therapy.

Mitsuaki Oura, Masanori Toho, Daisuke Ikeda, Naoya Fukuda, Ana Salinas Torres, Fuminari Fujii, Hajime Sakuma, Atsushi Uehara, Rikako Tabata, Kentaro Narita and 2 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mitsuaki OuraDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Masanori TohoDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Daisuke IkedaDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Naoya FukudaDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Ana Salinas TorresDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Fuminari FujiiDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Hajime SakumaDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Atsushi UeharaDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Rikako TabataDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Kentaro NaritaDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Masami TakeuchiDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Kosei MatsueDivision of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neurolymphomatosis frequently impairs physical function, rendering patients unable to tolerate chimeric antigen receptor T-cell therapy (CAR-T). An alternative treatment strategy which can cross the blood-nerve barrier is warranted. Case: A 64-year-old woman had a history of Conclusion: This report is the first to demonstrate the effectiveness of epcoritamab in treating neurolymphomatosis. Bispecific antibodies may serve as a valuable bridging therapy for CAR-T, helping to restore their physical function. Bruton's tyrosine kinase inhibitors could also be an option for

Indexed as

bispecific antibodyBruton’s tyrosine kinase inhibitorcase reportchemotherapydiffuse large B-cell lymphomaepcoritamabibrutinibneurolymphomatosis

Identifiers

PMID41907623
PMCPMC13017368

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.