ArticleFrontiers in endocrinology2026
Salivary microbiota signatures of periodontitis are associated with CGM-derived short-term glycaemic control in adults with type 1 diabetes: a pilot study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Aims: Periodontitis is common in type 1 diabetes (T1D), yet its relationship with short-term glycaemic control remains unclear. Continuous glucose monitoring (CGM) provides complementary metrics to HbA1c, including Time in Range (TIR) and Time Above Range (TAR). We investigated whether periodontitis-associated salivary microbiota signatures are associated with CGM-derived short-term glycaemic metrics in adults with T1D. Methods: In this pilot cross-sectional study, 24 adults with T1D were classified using the Community Periodontal Index as gingivitis (CPI 1-2; n=12) or periodontitis (CPI 3-4; n=12). Oral indices, HbA1c and CGM metrics were collected. Salivary microbiota was profiled by 16S rRNA gene sequencing. Differential abundance, inferred functional profiling, and multivariate association analyses were used to relate microbial signatures to CGM metrics. Results: Compared with gingivitis, periodontitis was significantly associated with lower TIR (40.5% Conclusions: In this cohort of adults with T1D, periodontitis was associated with distinct salivary microbiota signatures varied along with CGM-derived short-term glycaemic metrics, despite similar HbA1c. If confirmed in larger longitudinal studies, salivary profiling may be an interesting complement for CGM-based assessment to support integrated periodontal and metabolic follow-up.
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