Sit-to-stand and stand-to-sit transitions stimulate cardiac autonomic regulation and lead to age-dependent short-term patterns in heart rate.

Background: Sedentary behaviors pose health risks, which can be mitigated by regular exercise. The impact of everyday movements on cardiac autonomic regulation is not well-established. The present study investigated whether standing up and sitting down from a chair leads to a reproducible transition pattern in heart rate. Furthermore, age-related changes in this pattern were assessed. Methods: Forty healthy participants (18-65 years, 22 female) performed eight repetitions of standing up from a chair and sitting down. Electrocardiogram and accelerometer data were recorded throughout the procedure. The average RR interval series was used to quantify the transition pattern evoked by the movement. Results: Both movements resulted in a transition pattern in the RR interval and corresponding heart rate (HR) series within 30 s. After the initiation of movement, a local maximum HR appeared at a median of 8.1 s (standing up, HR Conclusion: Standing up from a chair and sitting down each briefly stimulate cardiac autonomic regulation. The transition process partially slows down and becomes less pronounced with increasing age. Increasing the daily amount of standing up contributes to cardiac autonomic regulation flexibility and helps mitigating cardiovascular risks from sedentary behaviors. Trial Registration: https://drks.de, Unique identifier: DRKS00021712.