ReviewFrontiers in bioengineering and biotechnology2025
Role of metal nanomaterials in wound healing - a review.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Wound Healing Potential of Multifunctional Nanomaterials: Mechanism, Future Prospects, and Challenges.Pharmaceutics · 2026Review
- Evaluated Wound Healing Property ofPharmaceutics · 2026Article
- Iron-oxide nanoparticle-integrated soft contact lenses: optical optimization, catalytic functionality, and biocompatibility.Frontiers in medical technology · 2026Article
- Emerging Nanomaterials Can Even Treat Chronic Wounds: A Review of Evidence on Magnesium-Based Systems.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wounds pose a significant burden in a patient's life. Nanotechnology has developed a new era of wound healing through the introduction of nanoparticles. This paper reviews the performance of various metallic nanoparticles, like silver, gold, titanium, magnesium, cerium, and zinc in bacterial reduction, inflammation control, and wound healing when incorporated into wound healing patches. MNPs exhibit antibacterial and anti-inflammatory properties, primarily through reactive oxygen species generation and the release of metallic ions, leading to bacterial cell wall disruption and nutrient deprivation. Their presence at the wound site accelerates healing, enhances wound closure, and promotes cell proliferation. For instance, gold nanoparticles with hydrogels have shown an effectiveness of more than 95% against certain strains and an enhancement in wound healing and closure. Additionally, copper nanoparticles have shown an effectiveness of more than 99% against certain strains and an advancement in the healing process. The review elaborates on the diverse hydrogels, antibacterial, and wound-healing mechanisms of different nanoparticles, as well as future pathways. However, concerns regarding the long-term toxicity of MNPs and immune responses due to prolonged exposure to metal ions remain, which is extensively discussed in the review. Additionally, research on MNPs beyond gold and silver nanoparticles is limited, necessitating further studies to understand their mechanisms and efficacy in wound healing applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.