Evidence map›Paper›PMID 41907501›Full record

ArticleACS central science2026

Target-Centric Multiplexed Screening of an Herbal Extract Identifies a Novel Dual A

Hongyue Liu, Xinyu Yang, Jingyi Xu, Yuefei Wang, Zichen Zhao, Ke Quan, Aoqi Gao, Yang Wang, Jingbo Wu, Fei Li and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hongyue LiuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Xinyu YangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Jingyi XuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Yuefei WangTianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID https://orcid.org/0000-0003-0956-6046
Zichen ZhaoiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Ke QuanShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Aoqi GaoShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yang WangDepartment of Urology and Department of Pathology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 201100, China.
Jingbo WuDepartment of Urology and Department of Pathology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 201100, China.
Fei LiiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Zhaoyu ZhangiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Yuanyuan MaiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Yuan WengShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Ying ChenShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Liping SuniHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Gaojie SongShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yibing ShaniHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Xin ChaiTianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Bingjie ZhangiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Weiqiang LuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID https://orcid.org/0000-0003-1349-6597
Wenqing ShuiiHuman Institute, ShanghaiTech University, Shanghai 201210, China.ORCID https://orcid.org/0000-0002-5245-2477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal herbs contain natural products (NPs) possessing rich scaffolds valuable for drug discovery, particularly in oncology. While most NP-derived cancer therapeutics directly kill tumor cells, emerging opportunities lie in modulating antitumor immunity. However, target-annotated NPs for cancer immunotherapy remain scarce. Herein we established a multiplexed platform combining virtual screening, affinity selection-mass spectrometry, and metabolomics profiling to identify bioactive NPs targeting the adenosine 2A receptor (A

Identifiers

PMID41907501
PMCPMC13022719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.