Site-Divergent Oxidations within Venerable Macrolide Antibiotic Scaffolds Unveil Compounds with Broad Spectrum and Anti-MRSA Activities.

Olivia C Langner, Brandon Q Mercado, Sebastian M Krajewski, Song Lin, Scott J Miller

Abstract read

In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Development of Keystone Macrolide Antibiotics via Selective Oxidation.ACS central science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olivia C LangnerDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0002-1875-8173

Brandon Q MercadoDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0002-1940-3497

Sebastian M KrajewskiDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0002-9755-2375

Song LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0002-8880-6476

Scott J MillerDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0001-7817-1318

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026

$6.3M

Radical redox catalysis by Ti complexesR01GM134088 · NIGMS · STANFORD UNIVERSITY · PI Song Lin · 2020 to 2026

$2.4M

NIGMS NIH HHS R01 GM134088NIGMS NIH HHS R35 GM132092

6 · The paper itself

Abstract

The synthesis of bioactive compounds with differential, and ideally enhanced, activities presents persistent and growing challenges for the field of organic synthesis. By leveraging Nature's ability to build complex, stereochemically rich, and biologically active molecular scaffolds, site-selective modification of natural products can deliver analogs without the need for lengthy

Identifiers

PMID41907500

DOI10.1021/acscentsci.5c02343

PMCPMC13022725

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.