ArticlePeerJ2026
Serum levels of PTEN and progranulin as potential diagnostic and prognostic biomarkers for severe pneumonia in the elderly.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Severe pneumonia presents a critical challenge clinically, especially for elderly patients. This study investigates the diagnostic and prognostic potential of serum Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) and Progranulin in this population. Objectives: To evaluate the effectiveness of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and Progranulin as diagnostic and prognostic biomarkers for differentiating severe pneumonia from common pneumonia in elderly patients, so as to enhance clinical practice. Methods: This comparative study was conducted on 90 elderly patients with severe pneumonia (Observation Group) and 90 elderly patients with common pneumonia (Control Group). Based on the survival outcome 28 days post-admission, the Observation Group was further divided into the Survival Group ( Results: Patients with severe pneumonia were measured with significantly higher white blood cells, CRP, procalcitonin, PTEN, and Progranulin levels (all Conclusion: Serum PTEN and Progranulin are promising diagnostic biomarkers for severe pneumonia in elderly patients, with Progranulin showing prognostic value in particular.
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