Evidence map›Paper›PMID 41907434›Full record

ArticleiScience2026

A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss.

Natalie Taege, Jan Hendric Britsemmer, Andreas Israel, Christin Krause, Sina Junge, Annette Feuchtinger, Siegfried Ussar, Paul Thomas Pfluger, Timo Gemoll, Sonja Charlotte Schriever and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalie TaegeInstitute for Human Genetics, Division Epigenetics & Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Jan Hendric BritsemmerInstitute for Human Genetics, Division Epigenetics & Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Andreas IsraelGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Christin KrauseInstitute for Human Genetics, Division Epigenetics & Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Sina JungeInstitute for Human Genetics, Division Epigenetics & Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Annette FeuchtingerCore Facility Pathology and Tissue Analytics, Helmholtz Munich, Neuherberg, Germany.
Siegfried UssarGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Paul Thomas PflugerGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Timo GemollDepartment of Surgery, Section for Translational Surgical Oncology and Biobanking, University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.
Sonja Charlotte SchrieverGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Henriette KirchnerInstitute for Human Genetics, Division Epigenetics & Metabolism, University of Lübeck, 23562 Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin gene (

Indexed as

epigeneticsHuman metabolism

Identifiers

PMID41907434
PMCPMC13019502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.