An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy.

Limin Ren, Enhe Kou, Wenqiang Zhang, Shixun Li, Xunwei Tong, Liwei Ren, Yisong Tan

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Limin RenSchool of Mechanical Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Enhe KouSchool of Mechanical Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Wenqiang ZhangCollege of Mechanical & Energy Engineering, Beijing University of Technology, Beijing 100124, China.

Shixun LiSchool of Mechanical Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Xunwei TongSchool of Mechanical Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Liwei RenSchool of Automation Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Yisong TanSchool of Mechanical Engineering, Northeast Electric Power University, Jilin, Jilin 132012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise and flexible drug delivery is increasingly required in clinical therapy, yet most implantable systems remain constrained by limited selectivity, low loading capacity, and bulky size. Here, we present an implantable capsule that employs magnetically actuated vibration of an internal metallic cantilever to achieve magnetically controlled release. The capsule integrates a dual-reservoir structure, enabling the device to load two drugs and support multimodal release through three independent modes. Experimental evaluation demonstrates a drug retention rate of 76% and a single release volume of 0.01 mL with fluctuations within ±0.0005 mL, while maintaining a miniature form factor (13 × 5 × 5 mm

Indexed as

BiodevicesBiotechnologyDrug delivery systemMagnetic materialsMaterials science

Identifiers

PMID41907430

DOI10.1016/j.isci.2026.115099

PMCPMC13018881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.