Evidence map›Paper›PMID 41907400›Full record

ArticleiScience2026

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

Eoghan J Mulholland-Illingworth, Joshua W Moore, Muyang Lin, Raheleh Amirkhah, Lucile Grzesiak, Amelia Ligeza, Joshua A Bull, Joseph Boen, Gabriel N Valbuena, Michael A Gillespie and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Eoghan J Mulholland-IllingworthCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Joshua W MooreWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.
Muyang LinCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Raheleh AmirkhahJohnston Cancer Research Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, UK.
Lucile GrzesiakCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Amelia LigezaCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Joshua A BullWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.
Joseph BoenCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Gabriel N ValbuenaCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Michael A GillespieCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Tamsin R M LannaganCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Kathryn GilroyCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Megan L MillsCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Shania M CorryCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Rachel A RidgwayCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Hayley L Belnoue-DavisCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Philip D DunneJohnston Cancer Research Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, UK.
Owen J SansomCancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.
Helen M ByrneCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.
Simon J LeedhamCentre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a complex ecosystem shaped by bidirectional interactions between epithelium and the tumor microenvironment, prominently mediated by TGFβ signaling. Cancer-associated fibroblasts (CAFs) are regulators of epithelial plasticity and immune cell recruitment; yet, their diversity has impacted translationally applicable spatial analysis. Here, we distil the fibroblast continuum into two overarching CAF populations that are largely transcriptomically distinct and are marked by PDGFRA

Indexed as

cancerhealth sciencesmedicineoncology

Identifiers

PMID41907400
PMCPMC13018967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.