Evidence map›Paper›PMID 41907384›Full record

ArticleOphthalmology science2026

Persistent Vision Loss of Eyes Lost to Follow-Up with Diabetic Macular Edema Receiving Intravitreal Anti-VEGF Therapy.

Chuandi Zhou, Yinchen Shen, Shu Li, Yong Li, Dongqing Zhu, Xiaorong Li, Xiaolu Yang, Yupeng Xu, Xian Wang, Ningyao Cao and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Chuandi ZhouDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Yinchen ShenDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Shu LiNational Clinical Research Center for Eye Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Yong LiDepartment of Ophthalmology, Calmette Hospital Affiliated to Kunming Medical University, Kunming, Yunnan Province, China.
Dongqing ZhuDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaorong LiTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiaolu YangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Yupeng XuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Xian WangDepartment of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Ningyao CaoDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dawei SunDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenfang ZhangDepartment of Ophthalmology, The Second Hospital & Clinical Medical School, Lanzhou University; Gansu Clinical Research Center for Eye Diseases, Lanzhou, China.
Suyan LiThe Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou Eye Disease Prevention and Treatment Institute, Xuzhou, China.
Han ZhangDepartment of Ophthalmology, First Hospital of China Medical University, Shenyang, China.
Hongbin LvDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
Xiang MaDepartment of Ophthalmology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Honghua YuGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zongming SongDepartment of Ophthalmology, Henan Provincial People's Hospital. Henan Eye Hospital, Zhengzhou, China.
Tianzi ZhangDepartment of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia, China.
Xuhui YuEye Hospital, the First Affiliated Hospital of Harbin Medical University; Key laboratory of basic and clinical research of Heilongjiang Province, Harbin, China.
Yong LiuDepartment of Ophthalmology, Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Tongtong NiuDepartment of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang Eye Research Institute, Key Laboratory of Ophthalmology of Liaoning, Shenyang, China.
Rongdi YuanDepartment of Ophthalmology, the Second Affiliated Hospital of Army Medical University, Chongqing, China.
Zhipeng YouThe Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Province Key Laboratory of Ophthalmology and Vision Sciences, Jiangxi clinical research center for ophthalmic disease, Jiangxi Provincial Key Laboratory of Vitreoretinal Diseases for Health, Nanchang, Jiangxi, China.
Qing LiuDepartment of Ophthalmology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanping SongDepartment of Ophthalmology, General Hospital of Central Theater Command, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Xiaodong SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Zhi ZhengDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Kun LiuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.
Xun XuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the visual and anatomic outcomes after being lost to follow-up (LTFU) among patients with diabetic macular edema (DME) that treated by intravitreal anti-VEGF therapies, and to determine the risk factors of persistent vision loss. Design: A retrospective cohort study using national registry data. Participants: A total of 5660 patients who were LTFU >6 months after anti-VEGF treatments from April 2020 through July 2024. Methods: Visual and anatomic outcomes at the visit before being LTFU, the return visit, 3 months, 6 months, and 12 months after return, and the final visit were collected. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of risk factors for persistent vision loss. Main Outcome Measures: Visual acuity (VA) and central foveal thickness (CFT). Results: After a mean LTFU period of 11.3 months, 2712 (47.9%) patients had vision decline at return visit. Identified risk factors included increasing age (45-64 years vs. ≤44 years: OR, 1.30; 95% CI, 1.07-1.56; Conclusions: Nearly half of the patients had vision decline after being LTFU, and after resuming therapies, vision loss still persisted in 2 of 3 patients. Clinical adherence should be strengthened for patients with baseline VA of 20/40 or better or having CFT of 350 μm or more at return. Multiple agents used were associated with vision recovery. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Anti-vascular endothelial growth factor therapyCohort studyDiabetic macular edemaLost to follow-upPersistent vision loss

Identifiers

PMID41907384
PMCPMC13019777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.