ArticleInternational journal of nanomedicine2026
Multimodal Imaging By Polydopamine Nanoparticles for Effective Pre- and Intra-Operative Lymph-Node Screening in Gastric Cancer Using Mice Model.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Engineering Nanocarriers for Dopamine Stabilization and Targeted Brain Delivery: Mechanisms, Approaches and Translational Challenges.International journal of nanomedicine · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Systematic lymphadenectomy is crucial in gastric cancer surgery for improving patient prognosis. However, current clinical lymph node (LN) mapping relies on fragmentary single-modal imaging agents, which suffer from low accuracy in N-staging and lack integration between preoperative and intraoperative visualization. Methods: We developed polydopamine-based nanoparticles (PEG-PDA@IR820/Gd(NH Results: The differently sized PPIG NPs exhibited tunable and size-dependent lymphatic drainage and retention. In mice, they enabled integrative pre-operative (MR) and intra-operative (optical/NIR fluorescence/thermal) multimodal mapping of popliteal LNs. In human specimens, PPIG NPs specifically delineated lymphatic vessels and LNs. Guided by this dual-modal (optical/NIR) mapping, lymphadenectomy in human gastric specimens achieved a significantly higher LN yield compared to conventional visual inspection (mean number: 55.4 vs 36.8, Conclusion: PPIG NPs provide an integrative pre- and intra-operative multimodal LN mapping platform. This strategy, enabling "see-before-cut" planning and "trace-while-cutting" navigation, demonstrates superior accuracy for LN and lymphatic vessel identification compared to current fragmentary techniques, showing promising potential for guiding precise lymphadenectomy in gastric cancer.
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