ArticleIndian journal of anaesthesia2026
Impact of paediatric malnutrition on sevoflurane requirements and recovery: A pilot study.
Article in Indian journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Malnutrition alters anaesthetic pharmacodynamics and pharmacokinetics, potentially affecting outcomes in children. We aimed to assess the impact of varying degrees of malnutrition on sevoflurane requirements, induction, and emergence times in children aged 2-9 years. Methods: This prospective observational study was conducted at a tertiary health care institute. Hundred children with American Society of Anesthesiologists physical status I-II, undergoing short ophthalmic procedures (<15 min) under general anaesthesia, were enroled after ethics committee approval. Anthropometry [weight, height, mid-upper arm circumference (MUAC)] was recorded. Anaesthesia was induced with incremental sevoflurane in a 1:1 oxygen: nitrous oxide (6 L/min) mix. Induction and emergence times were recorded, and sevoflurane requirements were estimated using Dion's method. Nutritional status was classified using the Centers for Disease Control and Prevention Z-scores into: well-nourished or mildly, moderately, or severely malnourished. Data were analysed using two-way analysis of variance with Tukey's test, and Pearson's correlation (GraphPad Prism 8.0.2); Results: Severely malnourished children exhibited significantly faster induction ( Conclusion: Severe malnutrition significantly alters anaesthetic response. MUAC may serve as a practical indicator for anaesthetic planning in such children.
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